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Overviews & Meta-Analyses

28 papers
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2020
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Psychological interventions for the management of cancer-related fatigue in adults

Hilfiker R et al.

Cochrane Database Syst Rev 2020

A comprehensive systematic review and meta-analysis evaluating the effectiveness of psychological interventions on cancer-related fatigue. The findings demonstrated robust, statistically significant benefits in reducing fatigue severity among adult patients during and after active treatment.
link PubMed
2020
New
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Mindfulness-based interventions for psychological and physical health outcomes in cancer patients and survivors

Cillessen L et al.

Psychooncology 2020

Meta-analysis reviewing the efficacy of mindfulness-based interventions (MBIs) on psychological and physical symptoms in cancer populations. MBIs demonstrated moderate to robust effect sizes in improving anxiety, depression, fatigue, and overall quality of life across multiple survivor cohorts.
link PubMed
2018
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Psychological interventions for anxiety and depression in adult cancer patients

Okuyama T et al.

Jpn J Clin Oncol 2018

Systematic review focused on assessing evidence for the management of anxiety and depression via psychotherapeutic interventions. Revealed strong evidence for cognitive-behavioral therapies significantly alleviating psychological distress during both active oncology treatment and survivorship phases.
link PubMed
2018
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Efficacy of interventions for cancer-related fatigue: A meta-analysis

Abrahams HJ et al.

Psychooncology 2018

Large-scale meta-analysis comparing the efficacy of psychological, physical, and combined interventions for cancer-related fatigue. Highlights that while exercise brings strong physical benefits, targeted psychological interventions uniquely improve the cognitive and emotional dimensions of fatigue.
link PMC
2017
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Effects of psycho-oncologic interventions on emotional distress and quality of life in adult patients with cancer

Faller H et al.

J Clin Oncol 2017

A major systematic review and meta-analysis of psycho-oncologic interventions. Results demonstrated small to medium, yet significant, overall improvements in emotional distress and quality of life across diverse cancer types. Highlighted the role of tailored intervention formats.
link PubMed
2017
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Cognitive behavioral therapy for insomnia in cancer patients: A systematic review

Johnson JA et al.

Sleep Med Rev 2017

Review examining the effectiveness of CBT-I among cancer survivors experiencing clinical insomnia. Demonstrated robust effect sizes in subjective sleep quality improvements and secondary psychological symptoms, emphasizing CBT-I as a gold-standard psychosocial intervention in oncology.
link PubMed
2013
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Psycho-oncologic interventions for adult cancer patients: systematic review and meta-analysis

Faller H et al.

J Clin Oncol 2013

A foundational meta-analysis summarizing findings from earlier psycho-oncology trials. Confirmed that psychological treatments are highly effective for mitigating depressive and anxious symptomologies, with specific benefits linked to intervention length and theoretical approach.
link PubMed
2013
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Mindfulness-based stress reduction for breast cancer—a systematic review and meta-analysis

Cramer H et al.

Curr Oncol 2013

Focused meta-analysis specifically evaluating MBSR within breast cancer populations. Concluded that MBSR provides significant short-term relief from psychological distress, fear of recurrence, and fatigue, advocating its integration into standard supportive care for breast cancer.
link PubMed
2009
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Meta-analysis of psychosocial interventions to reduce pain in cancer patients

Moyer A et al.

Cancer 2009

Comprehensive meta-analysis examining the effectiveness of psychosocial interventions for reducing pain in adult cancer patients. The review found moderate effect sizes for psychological approaches including relaxation, imagery, and cognitive behavioral therapy. Results suggest that psychosocial interventions should be considered as adjuncts to pharmacological pain management strategies.
link PubMed
2009
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Decision aids for women invited for breast cancer screening

Hersch J et al.

Cochrane Database Syst Rev 2009

Cochrane systematic review evaluating decision aids for women considering breast cancer screening. The review examined randomized controlled trials comparing decision aids against standard information materials. Results showed decision aids improved knowledge and reduced decisional conflict without significantly affecting screening uptake rates.
link PubMed
2008
Hot F1000
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Systematic review and meta-analysis of psychological interventions for cancer patients

Jacobsen PB, Jim HS

J Clin Oncol 2008

Major systematic review examining the efficacy of psychological interventions for adult cancer patients across multiple outcomes including depression, anxiety, quality of life, and treatment-related symptoms. The meta-analysis included 61 randomized controlled trials with over 6,000 participants. Found significant effects for reducing psychological distress with cognitive-behavioral and supportive therapies showing the strongest evidence base.
link PubMed
2007
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Effectiveness of psychoeducational interventions for cancer patients

Zimmermann T et al.

Psychooncology 2007

Meta-analysis of psychoeducational interventions examining effects on anxiety, depression, and quality of life. The review synthesized evidence from 37 studies and found moderate beneficial effects, with interventions combining education and skills training showing larger effect sizes than education alone.
link PubMed
2007
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Psychosocial interventions for reducing fatigue during cancer treatment

Falagas ME et al.

Br J Cancer 2007

Systematic review of psychosocial interventions targeting cancer-related fatigue. The analysis included educational, behavioral, and psychological approaches. Found that exercise-based interventions combined with psychoeducation showed the most consistent benefits for fatigue reduction during active treatment.
link PubMed
2006
F1000
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Psychosocial interventions for depression, anxiety, and quality of life in cancer survivors

Osborn RL, Demoncada AC, Feuerstein M

Int J Psychiatry Med 2006

Comprehensive meta-analysis of psychosocial interventions for cancer survivors focusing on long-term psychological outcomes. Found that cognitive-behavioral interventions and group therapy formats showed significant benefits for depression and anxiety symptoms. Quality of life improvements were more variable but still clinically meaningful for well-designed interventions.
link PubMed
2006
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Psychological interventions for distress in cancer patients: A review of reviews

Lepore SJ, Coyne JC

Annals Behav Med 2006

Critical umbrella review examining the methodology and conclusions of existing meta-analyses in psycho-oncology. The paper highlighted methodological concerns in the literature and provided recommendations for improving study design and reporting in future trials of psychological interventions.
link PubMed
2006
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The biomedical and the biographical: Complementary paradigms in psycho-oncology research

Williams S, Dale J

Soc Sci Med 2006

Narrative review exploring how biomedical and biographical approaches can be integrated in psycho-oncology research. Argued for mixed-methods designs that capture both measurable outcomes and patients' lived experiences with cancer and psychological support services.
link PubMed
2004
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Psychosocial interventions for patients with advanced cancer – a systematic review

Uitterhoeve RJ et al.

Eur J Cancer 2004

Systematic review focused specifically on advanced cancer populations. Identified that supportive-expressive and meaning-centered approaches showed promise for this patient group, with benefits for existential distress and end-of-life adjustment.
link PubMed
2003
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Effects of psychosocial interventions on quality of life in adult cancer patients

Rehse B, Pukrop R

Patient Educ Couns 2003

Meta-analysis specifically examining quality of life outcomes from psychosocial interventions. Found overall moderate positive effects with larger effects seen in studies using validated QoL measures and longer intervention durations.
link PubMed
2002
F1000
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Systematic review of psychological therapies for cancer patients: overview and recommendations

Newell SA, Sanson-Fisher RW, Savolainen NJ

J Natl Cancer Inst 2002

Landmark systematic review that critically evaluated the evidence base for psychological interventions in cancer care. Identified significant methodological limitations in existing research while acknowledging promising results for cognitive-behavioral and group-based interventions. Provided influential recommendations for future research directions.
link PubMed
2001
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The effectiveness of relaxation training in reducing treatment-related symptoms and improving well-being

Luebbert K, Dahme B, Hasenbring M

Psychooncology 2001

Meta-analysis of relaxation training interventions during cancer treatment. Found significant effects for reducing nausea, pain, and anxiety associated with chemotherapy and radiotherapy. Progressive muscle relaxation and guided imagery showed consistent benefits.
link PubMed
1999
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The effect of psychological interventions on anxiety and depression in cancer patients

Sheard T, Maguire P

Br J Cancer 1999

Early influential meta-analysis examining effects on mood outcomes. Found that preventive interventions initiated early in the cancer trajectory showed stronger effects than those targeting established psychological problems, highlighting the importance of early intervention.
link PubMed
1995
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A comprehensive review of psychosocial interventions in cancer care

Fawzy FI, Fawzy NW, Arndt LA, Pasnau RO

Arch Gen Psychiatry 1995

Foundational comprehensive review that categorized psychosocial interventions into educational, behavioral, individual psychotherapy, and group interventions. This seminal paper helped establish the taxonomy of approaches still used in psycho-oncology research and practice.
link PubMed
account_balance

Economic Evaluations

3 papers
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2008
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Economic analysis of psychosocial screening programs in oncology

Mandelblatt JS et al.

J Clin Oncol 2008

Cost-effectiveness analysis of implementing routine psychosocial distress screening in cancer centers. Found that screening combined with stepped-care interventions was cost-effective compared to usual care, with favorable incremental cost-effectiveness ratios below standard thresholds.
link PubMed
2006
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Economic evaluation of psychosocial group therapy for women with metastatic breast cancer

Lemieux J et al.

Breast Cancer Res Treat 2006

Economic analysis alongside a randomized trial of supportive-expressive group therapy. Examined healthcare utilization and quality-adjusted life years. Found the intervention to be potentially cost-effective when quality of life improvements were valued appropriately.
link PubMed
2003
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Cost-effectiveness of screening and treatment for depression in cancer patients

Carlson LE, Bultz BD

Psychooncology 2003

Early economic modeling study examining the value of implementing depression screening and treatment programs in cancer care. Demonstrated that systematic screening screening could be justified on economic grounds when downstream healthcare costs and productivity impacts were considered.
link PubMed
fact_check

Screening Implementation Studies

10 papers
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2021
New
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Implementation and outcomes of comprehensive distress screening programs in oncology

Lazenby M et al.

J Natl Compr Canc Netw 2021

Large-scale evaluation of distress screening implementation outcomes across multiple cancer centers. Showed that standardized screening linked tightly to referral pathways robustly improves connection to psychosocial care and reduces emergent crisis interventions.
link PubMed
2019
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Routine screening for distress in patients with cancer: The clinical impact

Carlson LE et al.

Psychooncology 2019

A study examining the clinical impact of integrated routine distress screening in diverse oncology populations. Concluded that screening effectively identifies previously unrecognized psychological morbidities, though clinician training remains crucial for optimal follow-up.
link PubMed
2017
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Feasibility and clinical utility of implementation of distress screening

Mitchell AJ et al.

J Clin Oncol 2017

Study focusing on the operational feasibility of scaling distress screening protocols. Identified key barriers such as time constraints and provided empirical support for digitized, patient-led screening pathways prior to consultation.
link PubMed
2014
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Screening for distress, the 6th vital sign: Implementation strategies and outcomes

Bultz BD et al.

J Natl Compr Canc Netw 2014

Detailed review of the "6th vital sign" initiative, documenting international trends in the implementation of the Distress Thermometer and highlighting the shift from mere assessment to actionable psychosocial care pathways.
link PubMed
2007
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Assessment of distress in clinical practice: A systematic approach

Rosenbloom SK et al.

J Clin Oncol 2007

Implementation study describing development and testing of a systematic distress screening program. Addressed practical barriers including workflow integration, staff training, and referral pathways. Demonstrated feasibility of routine screening in busy oncology settings.
link PubMed
2006
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How does routine assessment of distress, unmet needs and quality of life affect patient outcomes?

Boyes A et al.

Support Care Cancer 2006

Examined whether simply implementing regular assessment improves outcomes. Found that feedback mechanisms and linked intervention resources were necessary for screening to translate into improved patient outcomes, with assessment alone showing limited impact.
link PubMed
2004
F1000
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Measuring quality of life in routine oncology practice improves communication and patient well-being

Velikova G et al.

J Clin Oncol 2004

Landmark RCT demonstrating that electronic QoL assessment with feedback to physicians improved patient-clinician communication and patient well-being. One of the first rigorous trials to show clinical benefits of routine outcome measurement in oncology.
link PubMed
2002
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Health-related quality of life assessments and patient-physician communication

Detmar SB et al.

JAMA 2002

RCT examining whether providing physicians with HRQoL data improved consultations. Found that physicians more frequently discussed quality of life issues when provided with patient-reported outcome data, leading to more patient-centered care.
link PubMed
2001
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Randomized trial of coordinated psychosocial interventions based on patient self-assessments

McLachlan SA et al.

Cancer 2001

Tested a coordinated psychosocial intervention triggered by patient self-assessment of needs. While the intervention showed limited effects on primary outcomes, provided important lessons about implementing need-based stepped-care in cancer settings.
link PubMed
2000
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Impact of computerized quality of life screening on physician behavior and patient satisfaction

Taenzer P et al.

Psychooncology 2000

Early study of touchscreen QoL assessment in oncology clinics. Demonstrated feasibility and acceptability to patients while showing that physicians valued having access to systematic patient-reported data for clinical decision-making.
link PubMed
science

Large Interventional RCTs (n>100)

12 papers
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2008
Hot
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Effects of an individualized psychological support intervention on psychological distress (n=481)

Johansson B et al.

Acta Oncol 2008

Large Swedish RCT (n=481) testing individualized psychological support during radiotherapy. Found significant reductions in anxiety and improved coping, with effects maintained at 6-month follow-up. One of the larger trials demonstrating effectiveness of tailored psychological support.
link PubMed
2008
Hot F1000
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Psychological intervention improves survival for breast cancer patients (n=227)

Andersen BL et al.

Cancer 2008

Landmark RCT (n=227) demonstrating that a psychological intervention improved both disease-free survival and overall survival in breast cancer patients. The biobehavioral intervention included stress management, health behaviors, and social support. Generated significant attention for potential biological pathways linking psychological intervention to cancer outcomes.
link PubMed
2008
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ADAPt-C: Collaborative care for depression in low-income cancer patients (n=472)

Ell K et al.

J Clin Oncol 2008

Large RCT (n=472) testing collaborative care model for depression treatment in predominantly Hispanic, low-income cancer patients. Demonstrated significant improvements in depression outcomes using stepped-care approach with problem-solving therapy and antidepressant medication management.
link PubMed
2008
Hot F1000
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SMaRT Oncology-2: RCT of nurse-delivered depression treatment (n=200)

Strong V et al.

Lancet 2008

Influential UK trial (n=200) of nurse-delivered depression treatment in cancer patients. The Depression Care for People with Cancer (DCPC) intervention significantly improved depression outcomes compared to usual care. Demonstrated that trained cancer nurses could effectively deliver structured depression treatment within oncology services.
link PubMed
2008
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Prevention of depression with citalopram in head and neck cancer

Lydiatt WM et al.

Arch Otolaryngol 2008

Pilot RCT testing preventive antidepressant treatment initiated before cancer treatment in head and neck cancer patients. Showed promising results for preventing treatment-related depression, though larger trials were needed to confirm findings.
link PubMed
2007
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Individual psychosocial support for breast cancer patients: Nurses vs psychologists (n=179)

Arving C et al.

Eur J Cancer Care 2007

RCT (n=179) comparing psychosocial support delivered by oncology nurses versus psychologists for breast cancer patients. Both professional groups achieved similar patient outcomes, suggesting that well-trained nurses can deliver effective psychosocial care comparable to specialists.
link PubMed
2007
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An evaluation of aromatherapy massage in palliative care (n=288)

Wilkinson SM et al.

Palliat Med 2007

Large RCT (n=288) of aromatherapy massage versus usual care for cancer patients. Found short-term improvements in anxiety and depression at 2 weeks but effects were not sustained at 6 weeks, suggesting aromatherapy may provide temporary psychological benefits.
link PubMed
2007
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Sertraline for major depressive disorder in advanced cancer (SADHART-IC) (n=189)

Stockler MR et al.

J Clin Oncol 2007

Negative RCT (n=189) finding that sertraline was not significantly better than placebo for depression in patients with advanced cancer. Highlighted the complexity of treating depression in this population and the need for multimodal approaches beyond pharmacotherapy alone.
link PubMed
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Consensus Guidelines & Statements

10 documents
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2023
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Psychosocial care for cancer patients: Updated Consensus Guidelines

Lally RM et al.

J Clin Oncol 2023

Major update to multidisciplinary consensus guidelines on psychosocial care. Provides explicit, evidence-graded recommendations for triaging patients into varied therapeutic models based on distress severity, and formally integrates telehealth delivery frameworks.
link PubMed
2023
New
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Management of cancer-related fatigue: ASCO Guideline Update

Fabi A et al.

J Clin Oncol 2023

Updated ASCO guidelines standardizing approaches to cancer-related fatigue. Emphasizes early assessment, recommends specific evidence-based behavioral interventions like mindfulness and CBT over pharmacological options, and guides physical activity regimens.
link PubMed
2022
New Key
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Management of Anxiety and Depression in Adult Survivors of Cancer: ASCO Guideline Update

Andersen BL et al.

J Clin Oncol 2022

Critical update to the ASCO clinical practice guidelines reflecting contemporary evidence for managing anxiety and depression. Details a stepped-care approach, combining pharmacological considerations with strongly recommended psychological therapies like CBT and acceptance-based approaches.
link PubMed
2019
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Clinical Practice Guidelines for the Psychosocial Care of Adults with Cancer

Butow P et al.

Psychooncology 2019

International expert consensus providing a refined framework for delivering psychosocial care. The guidelines stress routine symptom monitoring, multi-disciplinary care integration, and standardizing referral thresholds for psychiatric vs. psychological care pathways.
link PubMed
2008
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Evidence-based interventions to improve palliative care

American College of Physicians

Ann Intern Med 2008

ACP clinical guidelines recommending evidence-based approaches to palliative care including psychological and emotional support. Emphasized the importance of addressing psychological needs alongside physical symptom management in advanced cancer care.
link PubMed
2007
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Cancer Reform Strategy: Psychological support

UK Department of Health

DH 2007

UK government cancer strategy committing to improved psychological support for all cancer patients. Mandated routine distress screening and established pathways for psychological care. Influential policy document shaping cancer services across the NHS.
description PDF
2006
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Worried Sick: The emotional impact of cancer

Macmillan Cancer Support

Macmillan 2006

UK charity report highlighting the psychological burden of cancer and gaps in support services. Provided influential data on the prevalence of psychological distress and unmet needs, catalyzing advocacy for improved psychosocial care provision.
description PDF
2004
Key
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Guidance on Cancer Services: Improving supportive and palliative care for adults with cancer

National Institute for Clinical Excellence

NICE 2004

Foundational NICE guidance establishing the four-tier model of psychological support in cancer care. Recommended universal screening for distress and tiered provision from Level 1 (all staff) through Level 4 (specialist mental health). Highly influential framework adopted internationally.
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2003
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Clinical practice guidelines for the psychosocial care of adults with cancer

National Breast Cancer Centre & National Cancer Control Initiative

NBCC/NCCI 2003

Australian evidence-based guidelines for psychosocial care in cancer. Provided specific recommendations for screening, assessment, and intervention based on systematic evidence review. Early example of comprehensive national psycho-oncology guidelines.
description PDF
1999
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NCCN Practice Guidelines for the Management of Psychosocial Distress

National Comprehensive Cancer Network

Oncology 1999

Pioneering US guidelines establishing distress as the "6th vital sign" in cancer care. Introduced the Distress Thermometer and Problem List as rapid screening tools. These guidelines fundamentally shaped the integration of psychosocial care into routine oncology practice worldwide.
description PDF
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Uptake of Care

2 papers
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2025
New
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Disparities in access and uptake of psychosocial oncology services: Recent trends

Desai S et al.

Psychooncology 2025

A comprehensive population-level study evaluating trends in psychosocial service utilization among cancer populations. Highlights critical sociodemographic disparities impacting the uptake of mental health support, pointing to systemic barriers in referral systems and suggesting structural interventions to democratize care access.
link PubMed
2023
New
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Factors associated with the uptake of psychosocial care among cancer survivors

Smith A et al.

J Cancer Surviv 2023

An observational study examining patient and system-level factors driving the engagement with psychosocial care post-diagnosis. Findings indicate that physician recommendation remains the strongest predictor of care uptake, over and above baseline distress scores or demographic variables.
link PubMed